논문검색

피부
저 자조소연1,2 정진호2
소 속서울대학교 보라매병
발행년도2007년 9월
출 처대한피부연구학회지 14권 3호 / 8~15page ( total : 8 page)
주제키워드Scleroderma, Pathogenesis, TGF-β, Collagen
첨부파일 14-3-008.pdf
Scleroderma is a heterogeneous group of disorders in which vascular and immunological disturbances lead to tissue fibrosis. Systemic sclerosis and limited cutaneous forms share similar pathogenesis: vascular endothelial damage followed by upregulation of adhesion molecules and chemotactic cytokines causes inflammatory cell recruitment and infiltration through endothelium to extracellular matrix. Subsequent activation of TGF-β pathway and other factors including CTGF, IL-1, IL-4, IL-6, endothelin-1 and TIMP-1 leads to activation of fibroblasts and overproduction of collagen. Endothelin-1 and PDGF cause transdifferentiation of vascular smooth muscle cells to myofibroblasts, which leads to narrowing of vessel lume